Introducing Lonza Capsules & Health Ingredients’ groundbreaking enteric manufacturing technology – the Capsugel® Enprotect® capsule. This unique bi-layer capsule with the Coni-Snap® secure closure design utilizes HPMC and HPMC-AS polymers. It protects acid-sensitive APIs and enables rapid dissolution release at pH 6.8 without the need for additional excipients. The bi-layer manufacturing technology streamlines drug development processes, while personalized oral dose customization enhances product differentiation. Partner with us to revolutionize the microbiome market, overcome enteric delivery challenges, and drive innovation in modern healthcare.

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International Journal of Pharmaceutics:

In Vitro: The dissolution characteristics of five capsules (Next Generation Enteric [NGE], Vcaps® Enteric [VCE], VCE DUOCAP® [VCE/VCE] system, Hard Gelatin Capsule [HGC] as negative control, and Creon® 10,000 U as market reference) were evaluated using an in vitro simulation of the stomach and upper intestinal tract with an acidic duodenal incubation (pH 4.5 for the first 10 min, pH 6 for the remaining 17 min) to simulate exocrine pancreatic insufficiency. Caffeine was a marker of capsule dissolution, and tributyrin to butyrate conversion measured pancrelipase activity. All capsules were filled with pancrelipase; the NGE, VCE, VCE/VCE, and HGC capsules also contained 50 mg caffeine. Caffeine was released first from the HGC capsule, followed by the VCE, NGE, and VCE/ VCE capsules. Pancrelipase activity followed this trend and demonstrated a similar activity level over time for the NGE, VCE/VCE, and Creon® capsules. The HGC formulation confirmed gastric degradation of unprotected pancrelipase. NGE capsules provided similar protection to the simple fill formulation as observed for the complex formulation of the Creon® capsule in a setting with increased pepsin activity and may hasten the time needed to go from formula development to first-in-human studies for pH sensitive drugs or those requiring small intestine targeting.

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Invivo: Many orally dosed APIs are bioavailable only when formulated as an enteric dosage form to protect them from the harsh environment of the stomach. However, an enteric formulation is often accompanied with a higher development effort in the first place and the potential degradation of fragile APIs during the coating process. Ready-to-use enteric hard capsules would be an easily available alternative to test and develop APIs in enteric formulations, while decreasing the time and cost of process development. In this regard, Lonza Capsugel® Next Generation Enteric capsules offer a promising approach as functional capsules.

The in vivo performance of these capsules was observed with two independent techniques (MRI and caffeine in saliva) in eight human volunteers. No disintegration or content release in the stomach was observed, even after highly variable individual gastric residence times (range 7.5 to 82.5 min), indicating the reliable enteric properties of these capsules. Seven capsules disintegrated in the distal part of the small intestine; one capsule showed an uncommonly fast intestinal transit (15 min) and disintegrated in the colon. The results for this latter capsule by MRI and caffeine appearance differed dramatically, whereas for all other capsules disintegrating in the small intestine, the results were very comparable, which highlights the necessity for reliable and complementary measurement methods. No correlation could be found between the gastric residence time and disintegration after gastric emptying, which confirms the robust enteric formulation of those capsules.

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Real-Time, Label-Free, Stress Free Protein Analysis. The Sartorius Octet® systems, built using label-free Bio-Layer Interferometry (BLI) optical technology, offer a fast, robust and fluidics-free approach to protein analysis.

The Octet® platform is a comprehensive tool for screening and characterizing molecular interactions such as protein-protein or protein-drug interactions. It enables a huge variety of applications performed at various stages of biologics development — from early selection to validation to manufacturing.

Download the brochure and learn more about the Octet® R Series Systems.

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Whether you are identifying and quantifying nitrosamines, identifying elemental impurities, or developing residual solvent method as per USP <467> on the Agilent 8890 GC, staying up to date with the latest technology as well as methods is equally important. Utilize Agilent’s scientific expertise with workflows to ensure you are compliant, productive and competitive.

Your Agilent representative will work with you to create a customized package of services based on your lab’s technologies and application needs:

• Method maintenance
• Method implementation
• Method optimization
• Method development

Support your entire pharma testing workflow with best-in-class analysis solutions from a trusted source. Rely on Agilent to provide all the instruments, software, standards, sample prep, columns, supplies, and support you need to simplify your workflow and your decision making.

Download the flyer to explore list of Pharma methods and applications now.

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Based on the flagship Agilent 8890 GC and 7697A headspace sampler, the Agilent 8697 and 8697 XL headspace samplers are the first with integrated GC communication. That means you can manage your gas chromatography workflows from a single interface—and spend more time on what matters.

Designed with sample handling in mind, the 8697 XL headspace sampler with up to 120 vials allows for uninterrupted throughput. These removable sample racks can be exchanged while the headspace sampler is operating, so, samples can be added until the whole job is done.

Unlike any other headspace, the 8697 XL headspace samplers communicate directly with Agilent 8890, 8860, and Intuvo 9000 gas chromatographs, enabling full visibility into flow path status. Touchscreen and browser interfaces consolidate this information for guided diagnostics, root cause analysis, performance tracking, GC evaluation, troubleshooting, and error detection.

Integrated intelligence also allows the GC and headspace sampler to work better together for optimized sequence throughput. If a GC run needs more time to complete, the sampler will automatically wait before injecting the next sample. Now that is bar raised for instrument intelligence.

Discover more on how volatile impurities in drug samples are analyzed using the fully-loaded Agilent 8697 XL intelligent headspace sampler.

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Agilent University delivers training to build job-ready skills that you can put to work. Learn the essentials of new techniques or master real-world applications with advanced methodologies. Improve lab operations and minimize downtime with courses covering troubleshooting, maintenance, sample prep, and software operations for chromatography, mass spectrometry, spectroscopy, and more.

Find the education style that best suits your training needs, when and where you need it:

• Classroom training provides hands-on learning—either in Agilent classrooms or directly at your site—for the most immersive experience. Extensive training manuals are also included.
• Virtual Instructor-led Training gives you the benefits of live, in-person training, without the need to travel.
• Self-paced e-learning courses and training subscriptions offer an affordable, on-demand option for you to learn anytime, anywhere, at any speed.

Download the brochure now.

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Lab relocations involve complex processes that require a high level of planning and preparation to enable successful moves without compromising on productivity and science.

Our experienced personnel handles every aspect of your move:

– Relocation planning and documentation

– Layout consultation for your new site

– Deinstallation, reinstallation, and performance verification

– Instrument requalification and compliance testing

– Inventory management

– Post-move documentation

We move it all. From your Non-Agilent instruments down to your favourite pen that lives in the back of the drawer. No matter the destination or distance, we can handle it.

Download the brochure and understand how Agilent experts can help you Reduce Downtime, Maximize efficiency during lab relocation.

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Your business depends on access to new, productive instrumentation, but the pace of evolving technology and regulatory requirements make equipment ownership risky, especially in the face of shrinking capital budgets. Flexible payment plans from Agilent can help you acquire your next instrument without the capital expenditure.

Our Technical Knowledge and financial expertise enable us to equip you with customized financial solutions catered to your specific business requirement.

Key Highlights:

• Upto 100% financing of the asset
• Quick way to purchase new or upgrade existing asset
• Preserve business credit lines
• Customized payment plans
• NOC from existing bankers not required
• Enhance purchasing power

Download the brochure now.

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Perform real-time imaging and analysis of cell health, movement, morphology and function directly from your incubator over days, weeks or months, with Incucyte Live-Cell Analysis systems.

These systems from Sartorius are designed to efficiently capture cellular changes where they happen – in the incubator. Capture high-resolution fluorescence and bright field images and record data in real-time over hours, days or weeks. From proliferation assays to immune killing of tumour spheroids, this flexible system enables users to observe and quantify complex biological changes in real-time. Integrated software simplifies data analysis to speed up time to answer while producing publication-quality graphs and plots.

The various types of Incucyte Live-Cell Analysis systems are as follows:

Incucyte® SX5 Live-Cell Analysis System

Incucyte® S3 Live-Cell Analysis System

Incucyte® SX1 Live-Cell Analysis System

To get Insights from Incucyte® Live-Cell Analysis Systems download the whitepaper.

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